Acetic Anhydride → HCID 67981720, compound

HRID 705376Notes

Reaction equation

HRID 705376 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[C:10]([CH:11]=[N:12]O)=[C:4]2[CH:3]=1.C(OC(=O)C)(=O)C>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[C:10]([C:11]#[N:12])=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 131733688HCID 131733688, compound

Product 1

HCID 67981720HCID 67981720, compound

Procedure

A mixture of Example 19E (3.09 g, 8.93 mmol) in acetic anhydride (100 mL, 1060 mmol) was heated at 140° C. for 24 hours, cooled and concentrated. The residue was triturated with diethyl ether to give a brown solid that was collected by filtration and dried (2.33 g, 80%). MS (ESI+) m/z 328/330 (M+H)+.

Workup

  1. temperaturecooled
  2. concentrationconcentrated
  3. customThe residue was triturated with diethyl ether
  4. customto give a brown solid
  5. filtrationthat was collected by filtration
  6. customdried (2.33 g, 80%)

Sources & evidence

ORD record
ord-05a8eca4e67b489ebf61438536c84ff9
Source dataset
uspto-grants-2015_11
Patent number
US09173887B2

Reaction notes

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