HCID 67983327, compound → HCID 86698217, compound

Participants

Reaction Steps

To a stirred solution of dimethyl 2-methoxyphenylphosphonite (1.0 g, 5.0 mmol) in diethyl ether (40 mL) at 0° C. is added dropwise over 30 minutes a solution (1 M) of (4-chlorophenyl)magnesium bromide in diethyl ether (10.5 mL, 10.5 mmol). After allowing to warm to room temperature, the mixture is filtered and stripped to give an oil that is triturated with MeOH to give a white solid (0.98 g, 58%) 1H NMR (C6D6): δ 7.09 (m, 5H), 7.03 (m, 4H), 6.78 (m, 1H), 6.74 (m, 1H), 6.47 (d of d, 1H, J=8.2, 4.7), 3.16 (s, 3H); 13C NMR (C6D6): δ 161.47 (d, 1C, JCP=15.1 Hz), 135.88 (d, 2C, JCP=13.8 Hz), 135.52 (d, 4C, JCP=21.4), 135.30 (s, 2C), 133.74 (d, 1C, JCP=2.6 Hz), 130.86 (s, 1C), 128.99 (d, 4C, JCP=6.6 Hz), 125.60 (d, 1C, JCP=14.2 Hz), 121.47 (s, 1C), 110.64 (s, 1C), 55.15 (s, 1C); 31P NMR (C6D6) δ-16.54. Elemental analysis calculated for C19H15Cl2OP: C, 63.18; H, 4.19; 0, 4.43; P, 8.58. Measured: C, 63.31; H, 4.40.

Provenance & Evidence