HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 705440Generated: October 30, 2026
N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide
https://huagongshe.com/reaction/705440
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide | HCID 66571290 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide | HCID 10095002 | — |
Reaction Steps
3.0 g of N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide (IV) is dissolved in 300 ml of methanol and 5 g of Raney-Ni catalyst is added. The mixture is stirred at 25° C. at 10 bar H2 pressure for 24 hours. The catalyst is filtered, and the solvent is evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174959B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-894e23c40a4f4589840c0a3566317d44 |
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| Source note | uspto-grants-2015_11 |
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