HCID 66571292, compound → HCID 66571291, compound

HRID 705442Notes

Reaction equation

HRID 705442 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([CH2:12][CH2:13][CH2:14][CH3:15])=[C:9]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][C:27]#[N:28])=[CH:20][CH:19]=3)=[O:17])[C:8]=2[CH:29]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([CH2:12][CH2:13][CH2:14][CH3:15])=[C:9]([C:16]([C:18]3[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH2:26][C:27]#[N:28])=[CH:22][CH:23]=3)=[O:17])[C:8]=2[CH:29]=1

Participants

5

Reactant 2

HCID 66571292HCID 66571292, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66571291HCID 66571291, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

1 g of (5-nitro-2-butyl-benzofur-3-yl)-[4-(2-cyanoethoxy)phenyl]methanon (VII) is dissolved in 15 ml of methanol and 0,1 g of 10 w/w % wet Pd/C catalyst is added and the reaction mixture is heated to 50° C. with a stirring of 800 round/min. Hydrogen pressure of 5 bar is set in the reactor and the mixture is stirred at this temperature for 2 hours. After cooling to room temperature the catalyst is, filtered off and the solvent is evaporated.

Workup

  1. temperatureAfter cooling to room temperature the catalyst
  2. filtrationfiltered off
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-ed995936ee314c9296b84f6a3c1fbcfb
Source dataset
uspto-grants-2015_11
Patent number
US09174959B2

Reaction notes

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