HuagongsheHuagongshe Chemistry Print Report · For research reference only
HOAt → HCID 45274191, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HOAt | HCID 181649 | — |
| Reactant | (4S)-5-(tert-butoxy)-4-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid | HCID 6993444 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 131733694 | HCID 131733694 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 45274191 | HCID 45274191 | — |
Reaction Steps
Boc-Glu-OtBu (303 mg, HOAt (136 mg, 1 mmol) and HATU (380 mg, 1 mmol) were dissolved in 1 mL of DMF, and triethylamine (0.278 ml) was added thereto. 10 minutes later, the mixture of monomethyl(3-aminophenyl)phosphonate and dimethyl ester was added thereto and stirred at room temperature overnight. After removing a solvent, purification was conducted in accordance with the purification process A to obtain a title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174932B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b915c66f4c1248d78e96f331140237bc |
| Source note | uspto-grants-2015_11 |