Pyridine → HCID 67312186, compound

Participants

Reaction Conditions

Reaction Steps

2-methoxy-4-nitroaniline (3 g, 17.8 mmol) was dissolved in THF (60 ml) and pyridine (1.6 ml, 19.6 mmol) was added. The reaction mixture was cooled to 0° C. and Fmoc-Cl (5.07 g, 19.6 mmol) was added in small portions. The reaction was allowed to come to ambient temperature and held for 5 hours. The reaction mixture was concentrated under reduced pressure. The crude product was purified by recrystallisation from CH2Cl2 and MeOH to afford the title compound (6.08 g, 88%). Data: (m/z)=391 (M+H)+.

Provenance & Evidence