Ethanol → HCID 49856399, compound

HRID 705506Notes

Reaction equation

HRID 705506 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.C([OH:24])C>>[OH2:24].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 702EthanolHCID 248987326-(1H-Imidazol-1-yl)-2-phenylquinazoline

Product 1

HCID 49856399HCID 49856399, compoundYield 75%

Procedure

3 g of 6-(1H-imidazol-1-yl)-2-phenylquinazoline are suspended in 80 mL of ethanol, the suspension is heated at reflux for 10 minutes, and then filtered while hot, the resulting solution is added at room temperature to 80 mL of water, with stirring, stirring is continued for a further 5 min and the mixture is then filtered and dried at 20° C., 10 mmHg, for 12 hours. 2.3 g (75%) of product are obtained in the form of a yellow powder. The crystals obtained are analysed. XRPD: Form C. Form C is similarly obtained by precipitating the product from methanol/H2O.

Workup

  1. temperaturethe suspension is heated
  2. temperatureat reflux for 10 minutes
  3. filtrationfiltered while hot, the resulting solution
  4. additionis added at room temperature to 80 mL of water
  5. stirringstirring
  6. filtrationthe mixture is then filtered
  7. customdried at 20° C.
  8. wait10 mmHg, for 12 hours

Sources & evidence

ORD record
ord-98b4c4c802484926a6b32ffed0fd4ad4
Source dataset
uspto-grants-2015_11
Patent number
US09174966B2

Reaction notes

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