Maleic Acid → HCID 67481355, compound

Participants

Reaction Conditions

Reaction Steps

6-(1H-Imidazol-1-yl)-2-phenylquinazoline, 136 mg (0.5 mmol), is dissolved in a mixture of isopropanol (15 mL) and water (0.5 mL) at reflux, with stirring at 50° C., 60 mg (0.5 mmol) of maleic acid are added, the mixture is stirred for 30 min. at 40° C., and then cooled to 0° C., and the resulting suspension is stirred at 0° C. a few minutes, filtered, washed with cold isopropanol and dried at 30° C., 20 mmHg, for 5 hours. 120 mg of product are obtained, XRPD: form A+form B as in FIG. 51.

Provenance & Evidence