反应详情

Potassium hydroxide (1.32 g) and 1-bromo-2-methylpropane (1.04 mL) were added to a solution of 2-(4-bromophenyl)ethylalcohol (140 μL) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, followed by extraction with dichloromethane. The organic layer was filtered through diatomaceous earth and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only) to give the title compound as a colorless oil (180 mg, 70%).

1. extractionfollowed by extraction with dichloromethane
2. filtrationThe organic layer was filtered through diatomaceous earth
3. customthe filtrate was evaporated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (hexane only)