Vanillin → 3-Chloro-4-hydroxy-5-methoxybenzaldehyde

Participants

Reaction Steps

To a solution of 50.0 g (330 mmol) of vanillin in 250 mL of glacial acetic acid was added chlorine gas through a glass tubing over 60 minutes (with a slow gas flow) at 25° C. White solid product was collected by filtration, washed with 300 mL of hexane, and dried in vacuum to give the title compound (36.0 g; 58%).

Provenance & Evidence