Ethanol → (1R,3S,6S)-tert-butyl-3-(aminomethyl)-2-azabicyclo[4.1.0]heptane-2-carboxylate

Participants

Reaction Steps

To a solution of D8 (11 g, 30.9 mmol) in ethanol (200 mL) hydrazine hydrate (7.28 mL, 150 mmol) was added and the mixture was stirred at room temperature for 16 hours. The precipitate was filtered off and the filtrate was concentrated. Then i-Pr2O was added, the precipitate was discarded and the filtrate was concentrated to give the title compound as yellow oil. Yield (6.7 g, 96%).

Provenance & Evidence