HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 705833Generated: October 30, 2026
4-Chloro-3-(trifluoromethyl)phenol → 4-(4-Chloro-3-trifluoromethyl-phenoxy)-3-fluoro-benzaldehyde
https://huagongshe.com/reaction/705833
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| Reactant | 3,4-Difluorobenzaldehyde | HCID 588088 | — |
| Product | 4-(4-Chloro-3-trifluoromethyl-phenoxy)-3-fluoro-benzaldehyde | HCID 86666198 | 80.2% |
Reaction Steps
The mixture of 4-chloro-3-(trifluoromethyl)phenol (7.61 g, 38.7 mmol), 3,4-difluorobenzaldehyde (5.0 g, 35.2 mmol) and CS2CO3 (11.46 g, 35.2 mmol) was heated with a microwave reactor at 80° C. for 1 h. Purification via a flash column chromatography then afforded the title compound (9.0 g, 80% yield). LCMS: rt=3.80 min, [M+H+]=319
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174968B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-3c1cece4f79b4c268fe9a14f5b3957a9 |
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| Source note | uspto-grants-2015_11 |
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