Thionyl Chloride → 4-(Chloromethyl)phenyl 4-chloro-3-(trifluoromethyl)phenyl ether

HRID 705849노트

반응식

HRID 705849 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15]O)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].S(Cl)([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][Cl:23])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 66825563(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol

생성물 1

HCID 668255374-(Chloromethyl)phenyl 4-chloro-3-(trifluoromethyl)phenyl ether수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the solution of (4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methanol (3 g, 9.91 mmol) in DCM (90 mL), was added thionyl chloride (7.5 mL, 103 mmol) dropwise. The mixture was stirred at room temperature for 1.5 h. After removing the solvent, the residue was dissolved in DCM, then washed with water twice, dried over Na2SO4. Concentration in vacuo afforded the title compound (2.8 g, 88% yield) as light brown oil. LCMS: rt=4.14 min

후처리

  1. customAfter removing the solvent
  2. dissolutionthe residue was dissolved in DCM
  3. washwashed with water twice
  4. dry with materialdried over Na2SO4
  5. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-7f34a9afe246484ba11c643b8ad8b8b8
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174968B2

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