Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-pyrimidinecarboxylate | HCID 735952 | — |
| Reactant | 4-(Chloromethyl)phenyl 4-chloro-3-(trifluoromethyl)phenyl ether | HCID 66825537 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178469905 | HCID 178469905 | 100% |
Reaction Steps
A mixture of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (1.016 g, 5.07 mmol), 1-chloro-4-{[4-(chloromethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (1.793 g, 5.58 mmol) and K2CO3 (0.771 g, 5.58 mmol) in DMF (15 mL) was heated with a microwave reactor at 80° C. for 0.5 h. The mixture was poured into 100 mL water and extracted with EA. The organic phase was dried over sodium sulfate, filtered, and concentrated to afford the title compound (2.461 g, 5.07 mmol, 100% yield). LCMS: rt=3.64 min, [M+H]=485
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174968B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-9a1a11db9e654ee8b492bdc7fd13dc1b |
|---|
| Source note | uspto-grants-2015_11 |
|---|
