反应详情

To the solution of 1-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethanone (3.12 g, 9.91 mmol) in Ethanol (60 ml), was added NaBH4 (0.450 g, 11.90 mmol). The solution was stirred at room temperature under nitrogen for 1 h. After removing the solvent, the residue was dissolved in DCM, then washed with water twice. The solvent was dried over Na2SO4, concentrated to afford the title compound (2.3 g, 73.2% yield) as light yellow oil. LCMS: rt=3.63 min, [M+H+]=299

1. customAfter removing the solvent
2. dissolutionthe residue was dissolved in DCM
3. washwashed with water twice
4. dry with materialThe solvent was dried over Na2SO4
5. concentrationconcentrated