Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tyrosol | HCID 10393 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67776411 | HCID 67776411 | 92% |
Reaction Steps
To a solution of 4-(2-hydroxyethyl)phenol (950 mg, 6.88 mmol) in DMF (15 mL) was added 2-chloropyrimidine (750 mg, 6.55 mmol) and K2CO3 (1086 mg, 7.86 mmol). The mixture was heated at 110° C. overnight. Purification via reverse phase flash chromatography then afforded the title compound (1.3 g, 6.01 mmol, 92% yield). LCMS: rt=1.85 min, [M+H+]=218
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174968B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-a9f08922841543909a9ec3f3cb569756 |
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| Source note | uspto-grants-2015_11 |
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