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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 705899Generated: October 30, 2026

Tyrosol → HCID 67776411, compound

https://huagongshe.com/reaction/705899

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTyrosolHCID 10393—
ReactantPotassium CarbonateHCID 11430—
Reactant2-ChloropyrimidineHCID 74404—
SolventDimethylformamideHCID 6228—
ProductHCID 67776411HCID 6777641192%

Reaction Conditions

Temperature110 °C

Reaction Steps

To a solution of 4-(2-hydroxyethyl)phenol (950 mg, 6.88 mmol) in DMF (15 mL) was added 2-chloropyrimidine (750 mg, 6.55 mmol) and K2CO3 (1086 mg, 7.86 mmol). The mixture was heated at 110° C. overnight. Purification via reverse phase flash chromatography then afforded the title compound (1.3 g, 6.01 mmol, 92% yield). LCMS: rt=1.85 min, [M+H+]=218

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09174968B2
Source datasetuspto-grants-2015_11
ORD IDord-a9f08922841543909a9ec3f3cb569756
Source noteuspto-grants-2015_11