反应详情

温度

0 °C

Entire reaction was performed under argon atmosphere using syringe septa technique. 5-(2-methoxy-pyrimidin-5-ylmethyl)-2-methylsulfanyl-1H-pyrimidin-4-one (0.984 mmol, 1 eq) was added in dry vessel. Boron tribromide (2.066 mmol, 2.1 eq) was added and reaction mixture was stirred at 0° C. After 30 min, reaction mixture was allowed to reach to room temperature and it was stirred overnight. Reaction mixture was diluted with water (2 ml). The resulting precipitate, 2-methylsulfanyl-5-(2-oxo-1,2-dihydro-pyrimidin-5-ylmethyl)-1H-pyrimidin-4-one (0.260 mmol, yield=26%) was obtained. 1H NMR (300 MHz, DMSO-d6) δ/ppm 2.45 (s, 3H), 7.75-7.88 (m, 2H), 7.97-8.33 (m, 3H), 11.29-13.09 (m, 4H)

1. customEntire reaction
2. customreaction mixture
3. customreaction mixture
4. customto reach to room temperature
5. stirringit was stirred overnight
6. customReaction mixture