関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)ethanamine | HCID 67775548 | — |
| 反応物 | HCID 178494135 | HCID 178494135 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178494131 | HCID 178494131 | 48.2% |
反応手順
To the solution of 5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-(nitroamino)-4(1H)-pyrimidinone (100 mg, 0.359 mmol) in ethanol (5 mL) was added neat 2-(4-{[4-chloro-3-(trifluoromethyl)-phenyl]oxy}phenyl)ethanamine (189 mg, 0.599 mmol). It was heated with a microwave reactor at 100° C. overnight. Purification via MDAP then afforded the title compound (92 mg, 35.6% yield). LCMS: rt=3.04 min, [M+H+]=532.2
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09174968B2 |
|---|
| 出典データセット | uspto-grants-2015_11 |
|---|
| ORD ID | ord-2e4a8da8ecfb4e77a9041e9da17d144e |
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| 出典メモ | uspto-grants-2015_11 |
|---|
