Potassium Carbonate → HCID 178518458, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl imidocarbamate triflate (120 mg, 0.236 mmol), ethyl 2-formyl-3-(2,4,6-trifluorophenyl)propanoate (154 mg, 0.591 mmol) and K2CO3 (98 mg, 0.709 mmol) in DMA (5 mL) was heated with a microwave reactor at 160° C. for 1 hour. Purification via MDAP then afforded the title compound (44 mg, 32.0% yield). LCMS: rt=4.14 min, [M+H+]=553.2

Provenance & Evidence