HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706024Generated: November 1, 2026
Potassium Carbonate → HCID 178518464, compound
https://huagongshe.com/reaction/706024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Z)-methyl 3-hydroxy-2-(pyrimidin-5-ylmethyl)acrylate | HCID 67774726 | — |
| Reactant | 2-(4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorophenyl)ethyl imidocarbamate | HCID 86666197 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178518464 | HCID 178518464 | 27% |
Reaction Steps
The mixture of 2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorophenyl)ethyl imidocarbamate (450 mg, 0.826 mmol), methyl (2Z)-3-hydroxy-2-(5-pyrimidinylmethyl)-2-propenoate (321 mg, 1.652 mmol) and K2CO3 (228 mg, 1.652 mmol) in NMP (5 mL) was heated with a microwave reactor at 160° C. for 1.5 h. Purification via MDAP then afforded the title compound (120 mg, 22.25% yield). LCMS: rt=3.46 min, [M+H+]=539
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174968B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-afd3303863d44d64a17beef058e5a33d |
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| Source note | uspto-grants-2015_11 |
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