HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706059Generated: October 26, 2026
Potassium Carbonate → HCID 178494159, compound
https://huagongshe.com/reaction/706059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(2-Methoxypyrimidin-5-ylmethyl)-2-thiouracil | HCID 21936244 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)phenyl 4-(2-iodoethyl)phenyl ether | HCID 67775359 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178494159 | HCID 178494159 | 8.55% |
Reaction Steps
A mixture of 1-chloro-4-{[4-(2-iodoethyl)phenyl]oxy}-2-(trifluoromethyl)benzene (400 mg, 0.938 mmol), 5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (258 mg, 1.031 mmol) and K2CO3 (259 mg, 1.875 mmol) in DMF (3 mL) was heated with a microwave reactor at 50° C. for 15 min. Purification via reverse phase flash chromatography then afforded the title compound (44 mg, 0.080 mmol, 8.55% yield). LCMS: rt=3.76 min, [M+H+]=549
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174968B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-4c8fbf5b2f6d43bc8f30bab1f8896a5b |
|---|
| Source note | uspto-grants-2015_11 |
|---|
