HCID 58452598, compound → HCID 58452640, compound

HRID 70606Notes

Reaction equation

HRID 70606 reaction equation
C1(SC2C=CC(C(C3C=CC(C)=C(OC)N=3)=O)=CC=2)CC1.[Si]([O:29][CH2:30][C:31]1([CH2:34][S:35]([C:38]2[N:42]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[N:41]=[N:40][N:39]=2)(=[O:37])=[O:36])[CH2:33][CH2:32]1)(C(C)(C)C)(C)C>>[C:43]1([N:42]2[C:38]([S:35]([CH2:34][CH:31]3[CH2:32][CH2:33][O:29][CH2:30]3)(=[O:37])=[O:36])=[N:39][N:40]=[N:41]2)[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1

Participants

3

Reactant 2

HCID 58452598HCID 58452598, compoundHCID 58452896HCID 58452896, compound

Product 1

HCID 58452640HCID 58452640, compound

Procedure

The title compound was obtained as a pale yellow solid (3.2 mg, 1% (three steps)) by performing substantially the same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except for using [4-(cyclopropylsulfanyl)phenyl](6-methoxy-5-methylpyridin-2-yl)methanone obtained in Reference Example 1-37 and using 5-({[1-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopropyl]methyl}sulfonyl)-1-phenyl-1H-tetrazole obtained in Reference Example 3-13 in place of 1-phenyl-5-[(tetrahydrofuran-3-ylmethyl)sulfonyl]-1H-tetrazole.

Workup

  1. customthe same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except
  2. customobtained in Reference Example 1-37

Sources & evidence

ORD record
ord-e52bc93f11614c44922f9677bb30a19b
Source dataset
uspto-grants-2014_09
Patent number
US08822503B2

Reaction notes

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