5-{[(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropyl]sulfonyl}-1-phenyl-1H-tetrazole → HCID 58452640, compound

HRID 70608Notes

Reaction equation

HRID 70608 reaction equation
[CH:1]1(SC2C=CC(C(C3C=CC(C(F)(F)F)=C(OC)N=3)=O)=CC=2)CC1.[Si]([O:42][CH2:43][C@H:44]([CH3:60])[CH2:45][S:46]([C:49]1[N:53]([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)[N:52]=[N:51][N:50]=1)(=[O:48])=[O:47])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[C:54]1([N:53]2[C:49]([S:46]([CH2:45][CH:44]3[CH2:60][CH2:1][O:42][CH2:43]3)(=[O:47])=[O:48])=[N:50][N:51]=[N:52]2)[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=1

Participants

3

Reactant 2

HCID 236429895-{[(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropyl]sulfonyl}-1-phenyl-1H-tetrazoleHCID 58452661HCID 58452661, compound

Product 1

HCID 58452640HCID 58452640, compound

Procedure

The title compound was obtained as a white solid (24 mg, 13% (three steps)) by performing substantially the same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except for using [4-(cyclopropylsulfanyl)phenyl][6-methoxy-5-(trifluoromethyl)pyridin-2-yl]methanone obtained in Reference Example 1-68 and using 5-{[(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropyl]sulfonyl}-1-phenyl-1H-tetrazole obtained in Reference Example 3-15 in place of 1-phenyl-5-[(tetrahydrofuran-3-ylmethyl)sulfonyl]-1H-tetrazole.

Workup

  1. customthe same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except
  2. customobtained in Reference Example 1-68

Sources & evidence

ORD record
ord-2c5ce928569444fdb006cdb9d8e948fa
Source dataset
uspto-grants-2014_09
Patent number
US08822503B2

Reaction notes

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