Potassium Carbonate → HCID 178518465, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 3,5-difluoro-4-((2-(trifluoromethyl)pyrimidin-5-yl)oxy)phenethyl carbamimidate, trifluoroacetate (100 mg, 0.210 mmol) and methyl 2-formyl-3-(pyrimidin-5-yl)propanoate (60 mg, 0.309 mmol) in 1,4-dioxane (1 mL) was added K2CO3 (116 mg, 0.842 mmol). The mixture was heated with a microwave reactor at 80° C. for 0.5 h. Purification via MDAP then afforded the title compound (36 mg, 0.071 mmol, 33.8% yield). LCMS: rt=2.82 min, [M+H]=507

Provenance & Evidence