Water → HCID 58452902, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (324 mg) and Oxone(R) (1.45 g) were sequentially added to a solution of 6-{2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethyl}-3-methylpyridin-2(1H)-one (154 mg) in acetone-water (10 mL) under ice-cooling, and the mixture was stirred at 0° C. for 30 minutes. The reaction solution was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and filtered. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=0:1) to give the title compound as a colorless amorphous (20 mg, 12%).

Provenance & Evidence