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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706166Generated: October 28, 2026

1-Bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester → 1-Cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester

https://huagongshe.com/reaction/706166

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl esterHCID 86617069—
ReactantHCID 178418546HCID 178418546—
Product1-Cyano-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl esterHCID 67110116—

Reaction Steps

The title compound was synthesized from 1-bromo-4-hydroxy-8-(4-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(+)-ion: M+1=351.4.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09174976B2
Source datasetuspto-grants-2015_11
ORD IDord-9af003f0467841e4b7b21c9e24b10dfc
Source noteuspto-grants-2015_11