HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester → 1-Cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester | HCID 86617070 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Product | 1-Cyano-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester | HCID 67110266 | — |
Reaction Steps
The title compound was synthesized from 1-bromo-4-hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester and CuCN in analogy to example 3a; MS-(+)-ion: M+1=351.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174976B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b677ac92433549fdb4ecbdd656d7dc17 |
| Source note | uspto-grants-2015_11 |