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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706187Generated: October 30, 2026

1-Bromo-6-(2-ethyl-6-methyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester → 1-Cyano-6-(2-ethyl-6-methyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester

https://huagongshe.com/reaction/706187

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-6-(2-ethyl-6-methyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl esterHCID 86617073—
ReactantHCID 178418546HCID 178418546—
Product1-Cyano-6-(2-ethyl-6-methyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl esterHCID 67110110—

Reaction Steps

The title compound was synthesized from 1-Bromo-6-(2-ethyl-6-methyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester and CuCN in analogy to example 3a; MS-(−)-ion: M−1=403.5.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09174976B2
Source datasetuspto-grants-2015_11
ORD IDord-c6c14fc14c7a459fbc93495a622f200f
Source noteuspto-grants-2015_11