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5-Aminobenzimidazole → HCID 178487637、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Aminobenzimidazole | HCID 13623 | — |
| 反応物 | 1,3-Benzodioxole-5-carboxaldehyde, 7-methoxy- | HCID 22016 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | Trimethylsilyl cyanide | HCID 82115 | — |
| 反応物 | Trifluoroacetate | HCID 84468 | — |
| 生成物 | HCID 178487637 | HCID 178487637 | — |
反応手順
The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 7-methoxybenzo[d][1,3]dioxole-5-carbaldehyde (0.721 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (0.521 mL, 3.74 mmol), di-(imidazol-1-yl)methanone (0.331 g, 2.04 mmol) as described in method 2. The product was purified by means of preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09173885B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-fb9324cce08e40c3b6aceb3d774131e6 |
| 出典メモ | uspto-grants-2015_11 |