HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminobenzimidazole → HCID 178517612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminobenzimidazole | HCID 13623 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 2,2-Difluoro-5-formylbenzodioxole | HCID 2736973 | — |
| Product | HCID 178517612 | HCID 178517612 | — |
Reaction Steps
The compound was synthesized starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 2,2-difluorobenzo[d][1,3]dioxole-5-carbaldehyde (0.744 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (0.81 mL, 5.81 mmol), di-(imidazol-1-yl)methanone (0.514 g, 3.17 mmol) as described in method 2. The product was purified by means of FPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09173885B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-5c06ece1e4d44e4393a5211b4dbdf283 |
| Source note | uspto-grants-2015_11 |