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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706284Generated: October 29, 2026

5-Aminobenzimidazole → HCID 178517683, compound

https://huagongshe.com/reaction/706284

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-AminobenzimidazoleHCID 13623—
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
ReactantTrimethylsilyl cyanideHCID 82115—
ReactantTrifluoroacetateHCID 84468—
Reactant2,6-DifluorobenzaldehydeHCID 136284—
ProductHCID 178517683HCID 178517683—

Reaction Steps

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 2,6-difluorobenzaldehyde (0.431 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.15 mL, 8.22 mmol), di-(imidazol-1-yl)methanone (0.730, 4.5 mmol) as described in method 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09173885B2
Source datasetuspto-grants-2015_11
ORD IDord-4c84a7ee78b94b66a6e65f133b262a78
Source noteuspto-grants-2015_11