HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 1-(1H-benzo[d]imidazol-6-yl)-5-(1-phenylpiperidin-4-yl)imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 1-Phenylpiperidine-4-carbaldehyde | HCID 13842992 | — |
| Reactant | HCID 178507353 | HCID 178507353 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-(1H-benzo[d]imidazol-6-yl)-5-(1-phenylpiperidin-4-yl)imidazolidin-2-one | HCID 58229075 | — |
Reaction Steps
The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.400 g, 3 mmol), 1-phenylpiperidine-4-carbaldehyde (0.570 g, 3 mmol), TMSCN (0.375 mL, 3 mmol), Pd/C (10%, 0.02 g), TEA 1.05 mL, 7.5 mmol), di-(imidazol-1-yl)methanone (0.730 g, 4.5 mmol) as described in method 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09173885B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-609b5e876eeb409fbe188076dcb968b6 |
| Source note | uspto-grants-2015_11 |