Veratraldehyde → HCID 178488768, compound

Participants

Reaction Steps

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.400 g, 3 mmol), 3,4-dimethoxybenzaldehyde (0.5 g, 3 mmol), TMSCN (0.375 mL, 3 mmol), Pd/C (10%, 0.02 g), TEA 1.05 mL, 7.5 mmol), di-(imidazol-1-yl)methanone (0.730 g, 4.5 mmol) as described in method 2 to give 1-(1H-benzo[d]imidazol-5-yl)-5-(3,4-dimethoxyphenyl)imidazolidin-2-one (yield: 0.3 g, 0.89 mmol, 29.7%). Treating with borontribromide (0.505 mL, 5.34 mmol) as described for example 151 gives the title compound.

Provenance & Evidence