Triethylamine → HCID 89535889, compound

Participants

Reaction Steps

To a mixture of tert-butyl 2-amino-5-nitrobenzylcarbamate (200 mg, 0.75 mmol) and triethylamine (76 mg, 0.75 mmol) in DCM was added acryloyl chloride (102 mg, 1.12 mmol). The mixture was stirred at rt for 48 h, and purified with column chromatography to give tert-butyl 2-acrylamido-5-nitrobenzylcarbamate. The tert-butyl 2-acrylamido-5-nitrobenzylcarbamate was dissolved in EtOH/HCl and stirred at rt for 1 h. Diethyl ether was then added and the solid formed was collected by filtration to yield the HCl salt of N-(2-(aminomethyl)-4-nitrophenyl)acrylamide (46 mg, 0.18 mmol).

Provenance & Evidence