1488325-95-6 → HCID 118023602, compound

HRID 706404Notes

Reaction equation

HRID 706404 reaction equation
O.O.O.[CH3:4][C@H:5]1[N:10]([CH2:11][C:12]([F:15])([F:14])[F:13])[C:9](=[O:16])[C@@H:8]([NH:17][C:18]([C:20]2[CH:21]=[C:22]3[CH2:37][C@@:27]4([C:35]5[C:30](=[N:31][CH:32]=[CH:33][CH:34]=5)[NH:29][C:28]4=[O:36])[CH2:26][C:23]3=[N:24][CH:25]=2)=[O:19])[CH2:7][C@H:6]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>C(#N)C>[C:9](#[N:10])[CH3:8].[CH3:4][C@H:5]1[N:10]([CH2:11][C:12]([F:15])([F:13])[F:14])[C:9](=[O:16])[C@@H:8]([NH:17][C:18]([C:20]2[CH:21]=[C:22]3[CH2:37][C@@:27]4([C:35]5[C:30](=[N:31][CH:32]=[CH:33][CH:34]=5)[NH:29][C:28]4=[O:36])[CH2:26][C:23]3=[N:24][CH:25]=2)=[O:19])[CH2:7][C@H:6]1[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

3

Reactant 1

HCID 1317336991488325-95-6

Product 1

HCID 118023602HCID 118023602, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent3×

Procedure

(S)—N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidine-3-yl)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide trihydrate was dissolved in acetonitrile until solution until material gelled. White solids formed out of the gel and this was suspended in additional acetonitrile and stirred overnight yielding crystalline acetonitrile solvate.

Workup

  1. customWhite solids formed out of the gel

Sources & evidence

ORD record
ord-ce616c9707854387aad7688559b12bf9
Source dataset
uspto-grants-2015_11
Patent number
US09174989B2

Reaction notes

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