1488325-98-9 → HCID 118023972, compound

HRID 706405Notes

Reaction equation

HRID 706405 reaction equation
O.[CH3:2][C@H:3]1[N:8]([CH2:9][C:10]([F:13])([F:12])[F:11])[C:7](=[O:14])[C@@H:6]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[CH2:35][C@@:25]4([C:33]5[C:28](=[N:29][CH:30]=[CH:31][CH:32]=5)[NH:27][C:26]4=[O:34])[CH2:24][C:21]3=[N:22][CH:23]=2)=[O:17])[CH2:5][C@H:4]1[C:36]1[C:41]([F:42])=[CH:40][CH:39]=[C:38]([F:43])[C:37]=1[F:44]>C(#N)C>[C:7](#[N:8])[CH3:6].[CH3:2][C@H:3]1[N:8]([CH2:9][C:10]([F:11])([F:12])[F:13])[C:7](=[O:14])[C@@H:6]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[CH2:35][C@@:25]4([C:33]5[C:28](=[N:29][CH:30]=[CH:31][CH:32]=5)[NH:27][C:26]4=[O:34])[CH2:24][C:21]3=[N:22][CH:23]=2)=[O:17])[CH2:5][C@H:4]1[C:36]1[C:41]([F:42])=[CH:40][CH:39]=[C:38]([F:43])[C:37]=1[F:44]

Participants

3

Reactant 1

HCID 1180235871488325-98-9

Product 1

HCID 118023972HCID 118023972, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide monohydrate was slurried in acetonitrile for 3 days yielding solids of an acetonitrile solvate.

Sources & evidence

ORD record
ord-a740e7f14d04456db54ab5ec1da3aae9
Source dataset
uspto-grants-2015_11
Patent number
US09174989B2

Reaction notes

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