反应详情

A suspension of Pemetrexed Monosodium in EtOH containing 0-2% water (v/v) was heated to reflux and 0.85 eq of aq. NaOH (30% w/w) were added. The mixture was stirred at reflux until PXRD showed complete conversion. 0.15 eq of aq. NaOH (30% w/w) were added and stirring under reflux was continued for 2 h before the suspension was cooled to 20° C. to 30° C. Pemetrexed Disodium Form IV was isolated by filtration, washed with EtOH and dried in vacuo at 50° C. at 5 mbar to constant weight.

1. temperaturewas heated
2. temperatureto reflux
3. temperatureat reflux until PXRD
4. stirringstirring
5. temperatureunder reflux
6. temperaturewas cooled to 20° C. to 30° C