反应详情

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen three times and then with hydrogen three times. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with N2, filtered through Celite and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give 4.36 g (93%) of ethyl 6-isopropylpicolinate.

1. customThe reaction mixture was purged with nitrogen three times
2. customA hydrogen balloon was applied to the reaction for three hours
3. customThe reaction was then purged with N2
4. filtrationfiltered through Celite
5. washwashed with EtOH (100 mL)
6. customSolvent was removed under reduced pressure