HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706536Generated: October 30, 2026
Dimethylformamide → 3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole
https://huagongshe.com/reaction/706536
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Chloromethyl)-6-isopropylpyridine hydrochloride | HCID 67974153 | — |
| Reactant | HCID 178526560 | HCID 178526560 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole | HCID 67975882 | 92% |
Reaction Steps
A flask was charged with 3-bromo-4-nitro-1H-indazole (64 g, 0.264 mol), 2-(chloromethyl)-6-isopropylpyridine hydrochloride (55 g, 0.264 mol), powdered potassium carbonate (91 g, 0.661 mol), and 500 mL of DMF. This mixture was warmed to 35° C. for 72 hours, then poured into 2 liters of cold water, upon which a tan solid precipitated. After stirring for 20 minutes, the solids were collected by filtration and dried under vacuum to give 91 g (92%) of 3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174981B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-1e2a864c99c54d15852079d11ef81b85 |
|---|
| Source note | uspto-grants-2015_11 |
|---|
