反应详情

To 6-cyclopropylpicolinaldehyde (3.5 g, 23.8 mmol) in methanol (95 mL) chilled to 0° C. was added sodium borohydride (2.70 g, 37.8 mmol). Once addition was complete, the cooling bath was removed and the reaction mixture was allowed to warm to ambient temperature. The mixture was concentrated under reduced pressure and the resulting residue was taken up in water, extracted with EtOAc, dried over sodium sulfate and concentrated under reduced pressure. Column chromatography (100% EtOAc as the eluent) of the crude material afforded 2.20 g (62%) of the title compound.

1. additionOnce addition
2. customthe cooling bath was removed
3. concentrationThe mixture was concentrated under reduced pressure
4. extractionextracted with EtOAc
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure