反应详情

温度

-15 °C

2-Fluoro-6-methylbenzoic acid (40 g, 0.26 mol) was dissolved in 320 mL of sulfuric acid and chilled to −15° C. To this was added 14 mL of fuming nitric acid in 60 mL of sulfuric acid over a 10 minute period. Once the addition was complete, the mixture was stirred at 0° C. for 1 hour, then poured into ice water, and stirred. The resulting solids were collected and then dissolved in EtOAc, which was washed with water, dried over sodium sulfate and concentrated to 50 g (97%) of the title compound.

1. additionOnce the addition
2. stirringstirred
3. customThe resulting solids were collected
4. dissolutiondissolved in EtOAc
5. washwhich was washed with water
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated to 50 g (97%) of the title compound