Lithium hydroxide, monohydrate → HCID 86699337, compound

Participants

Reaction Steps

Ethyl 7-(2-morpholinoethoxy)imidazo[1,2-a]pyridine-3-carboxylate 4-(2-morpholinoethoxy)pyridin-2-amine (1.0 g, 3.13 mmol) was dissolved in a 4:1 THF/water mixture (to a 0.5 M concentration). Lithium hydroxide monohydrate (75 mg, 3.13 mmol) was added and the resulting mixture was stirred overnight at ambient temperature, followed by heating at 65° C. for eight hours. An additional 0.1 equivalents of lithium hydroxide monohydrate was added, and heating at 65° C. was continued overnight. The reaction mixture was diluted with THF, filtered, concentrated, and dried under high vacuum to afford the crude product (0.979 g) as a pale yellow, free flowing solid.

Provenance & Evidence