Imidazo(1,2-a)pyridine-3-carboxylic acid → N-(1-benzyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

HRID 706706Notes

Reaction equation

HRID 706706 reaction equation
F[C:2]1[CH:18]=[C:17](F)[CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([NH2:14])[C:8]=2[CH:7]=[N:6]1.[N:20]1[CH:21]=[C:22]([C:29](O)=[O:30])[N:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=12.C(N1C2C=CC=C(N)C=2C=N1)C1C=CC=CC=1>>[CH2:4]([N:5]1[C:13]2[C:8](=[C:9]([NH:14][C:29]([C:22]3[N:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]4=[N:20][CH:21]=3)=[O:30])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6]1)[C:3]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:2]=1

Participants

4

Reactant 3

HCID 73142Imidazo(1,2-a)pyridine-3-carboxylic acidHCID 213273171-benzyl-1H-indazol-4-amineHCID 679761071-(2,4-difluorobenzyl)-1H-indazol-4-amine

Product 1

HCID 67990316N-(1-benzyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Procedure

Prepared according to the method of Example 109, replacing 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid and 1-(2,4-difluorobenzyl)-1H-indazol-4-amine with imidazo[1,2-a]pyridine-3-carboxylic acid and 1-benzyl-1H-indazol-4-amine, respectively. MS (APCI) m/z=368 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d37cbbd04a5244d9b54a991b1d8c868b
Source dataset
uspto-grants-2015_11
Patent number
US09174981B2

Reaction notes

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