1-(3-((4-nitro-1H-indazol-1-yl)methyl)piperidin-1-yl)ethanone → 1-(3-((4-amino-1H-indazol-1-yl)methyl)piperidin-1-yl)ethanone

Participants

Reaction Steps

A solution of 1-(3-((4-nitro-1H-indazol-1-yl)methyl)piperidin-1-yl)ethanone (0.022 g, 0.073 mmol) in MeOH (1 mL) was purged with Argon, treated with 10% palladium on carbon (0.002 g) purged with more Argon, and then attached to a hydrogen balloon. The mixture was stirred at ambient temperature overnight, filtered through glass fiber filter paper, washed with MeOH and concentrated to give 1-(3-((4-amino-1H-indazol-1-yl)methyl)piperidin-1-yl)ethanone (0.020 g, 100% yield) as an amber oil.

Provenance & Evidence