反应详情

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen and hydrogen three times each. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with nitrogen, filtered through Celite® and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give the desired product (93%).

1. customThe reaction mixture was purged with nitrogen and hydrogen three times each
2. customA hydrogen balloon was applied to the reaction for three hours
3. customThe reaction was then purged with nitrogen
4. filtrationfiltered through Celite®
5. washwashed with EtOH (100 mL)
6. customSolvent was removed under reduced pressure