HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-6-isopropylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (6-(Propan-2-yl)pyridin-2-yl)methanol | HCID 21874757 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Chloromethyl)-6-isopropylpyridine hydrochloride | HCID 67974153 | 98% |
Reaction Steps
To (6-isopropylpyridin-2-yl)methanol (3.13 g, 20.7 mmol) in DCM (20 mL) at 0° C. was added sulfurous dichloride (12.3 g, 104 mmol). The cold bath was removed and the reaction mixture was stirred for one hour. Solvent was removed under reduced pressure to give the desired product (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174981B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d6370ff8f8484258ac906857b636383c |
| Source note | uspto-grants-2015_11 |