HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(chloromethyl)-1-isopropyl-5-methyl-1H-pyrazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [5-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]methanol | HCID 23005569 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(chloromethyl)-1-isopropyl-5-methyl-1H-pyrazole hydrochloride | HCID 67974833 | 99% |
Reaction Steps
To (1-isopropyl-5-methyl-1H-pyrazol-3-yl)methanol (5.3 g, 34 mmol) in DCM (20 mL) at 0° C. was added sulfurous dichloride (20 g, 172 mmol). The cold bath was removed and the reaction mixture was stirred for one hour. Solvent was removed under reduced pressure to give the desired product (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174981B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-98bf553a43de4b1fb9c9e87ccf06f6f9 |
| Source note | uspto-grants-2015_11 |