HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706733Generated: October 30, 2026
Water → 6-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid
https://huagongshe.com/reaction/706733
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 6-fluoroimidazo[1,2-a]pyridine-3-carboxylate | HCID 67976050 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid | HCID 55268195 | 100.6% |
Reaction Steps
Ethyl 6-fluoroimidazo[1,2-a]pyridine-3-carboxylate (0.10 g, 0.48 mmol) and lithium hydroxide monohydrate (0.020 g, 0.48 mmol) were added to a mixture of water, THF and ethanol (1:2:1) and heated in a sealed vial at 65° C. for 6 hours. The solvent was removed by rotary evaporation to yield 87 mg of the desired product. MS (ES+APCI) m/z=181.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174981B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-d9a8e9c6dd164383b77d8541e4a5cd4e |
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| Source note | uspto-grants-2015_11 |
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