HCID 90010296, compound → HCID 136273996, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1-(4-methyl-benzoylamino)-1H-pyrrole-2-carboxylic acid amide (111 mg, 0.457 mmol) in 25% aqueous ammonia solution (0.7 ml) is heated to 100° C. in a closed reaction vial and stirred at this temperature for 40 hours. The reaction mixture is allowed to cool to room temperature and purged with nitrogen. Aqueous 1 N hydrochloric is added to reach a pH value of 2. The solids are filtered off and washed with water. Chromatography on a silica gel column with methanol/dichloromethane as eluent affords 2-p-tolyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one as white crystals; HPLC/MS 2.45 min (B), [M+H] 226;

Provenance & Evidence