Triethylamine → HCID 90010412, compound

Participants

Reaction Steps

Triethylamine (554 μl, 4.00 mmol) is added to a suspension of 1-amino-1H-pyrrole-2-carboxylic acid amide (501 mg, 4.00 mmol) in acetonitrile (8.0 ml). Then a suspension of methyl 4-chlorocarbonylbenzoate (264 μl, 2.00 mmol) in dichloromethane (4.0 ml) is added slowly. The reaction mixture is stirred at room temperature for 18 hours. The solvents are evaporated and the residue is triturated with water. The solid is filtered off, washed with water and dried under vacuum to give methyl 4-[(2-carbamoylpyrrol-1-yl)carbamoyl]benzoate as white crystals; HPLC/MS 1.45 min (C), [M+H] 288.

Provenance & Evidence